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Extravascular injection may perhaps lead to community tissue destruction with subsequent necrosis; penalties of intra-arterial injection might differ from transient discomfort to gangrene from the limb. Any complaint of pain within the limb warrants halting the injection.

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Animal info. Phenobarbital sodium is carcinogenic in mice and rats immediately after life span administration. In mice, it developed benign and malignant liver cell tumors. In rats, benign liver mobile tumors were observed really late in life.

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